Functional genomics in sand fly–derived Leishmania promastigotes
نویسندگان
چکیده
منابع مشابه
Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
A thorough understanding of the transmission mechanism of any infectious agent is crucial to implementing an effective intervention strategy. Here, our current understanding of the mechanisms that Leishmania parasites use to ensure their transmission from sand fly vectors by bite is reviewed. The most important mechanism is the creation of a "blocked fly" resulting from the secretion of promast...
متن کاملInfluence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture
Zoonotic visceral leishmaniasis is a vector-borne disease caused by Leishmania infantum in the Mediterranean Basin, where domestic dogs and wild canids are the main reservoirs. The promastigote stage replicates and develops within the gut of blood-sucking phlebotomine sand flies. Mature promastigotes are injected in the dermis of the mammalian host and differentiate into the amastigote stage wi...
متن کاملSurface antigens of Leishmania donovani promastigotes
Surface antigen profiles of Leishmania donovani promastigote isolates have been studied. Surface patterns of Brazilian and African isolates display remarkable similarities and are extremely simple, consisting of three major peptides of 65,000, 25,000, and 23,000 mol wt. Surface iodination and biosynthetic labeling coupled to immunoprecipitation techniques revealed that a single major determinan...
متن کامل1564 Surface Antigens of Leishmania Donovani Promastigotes
Leishmania donovani, the agent of visceral leishmaniasis , is a t r y p a n o s o m a t i d protozoan t r ansmi t t ed by ph leboto in ine sandflies. The paras i te cycles between a nonmot i le , in t race l lu la r amast igote stage paras i t iz ing the mononuc lea r phagocytes of the mammal ian host and an extracel lular , moti le p romas t igo te stage in the insect vector, A s imilar p roma...
متن کاملAntileishmanial Activity of Liposomal Clarithromycin against Leishmania Major Promastigotes
Objective(s)Cutaneous leishmaniasis is a common parasitic disease which is endemic in some parts of the world. In vitro and in vivo studies have shown azithromycin efficacy on some Leishmania species. Because of structural similarity between clarithromycin and azithromycin and efficacy of clarithromycin against intracellular organisms and due to the absence of previous studies in this respect, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2019
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0007288